PROTAC HPK1 Degrader-1
Product Specifications
CAS Number
3034182-97-0
Target
PROTACs, MAPK
Related Pathways
PROTAC, MAPK
Bioactivity
PROTACHPK1 Degrader-1 (Compound B1) is a potent HPK1 degrader with a DC50 value of 1.8 nM. It effectively inhibits the phosphorylation of the SLP76 protein, with an IC50 of 496.1 nM. As a genuine HPK1-PROTAC degrader, PROTACHPK1 Degrader-1 offers a valuable tool for further investigation into HPK1 in TCR signaling pathways.
Smiles
O=C1C=2C=CC=C(NCCOCCC(=O)N3CCN(C=4C=CC(=CC4)C5=CN=C6NC=C(C=7C=CC(OC)=C(OC)C7)C6=C5)CC3)C2C(=O)N1C8C(=O)NC(=O)CC8
Molecular Formula
C43H43N7O8
Molecular Weight
785.84
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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