SMU-L11

Product Specifications

Target

NF-?B|||MAPK|||TLR

Related Pathways

Immunology/Inflammation|||NF-?B|||MAPK

Bioactivity

SMU-L11 is a specific TLR7 agonist (EC50=0.024 ?M) that recruits the MyD88 adaptor protein, activating downstream NF-?B and MAPK signaling pathways. In mouse models, SMU-L11 significantly enhances immune cell activation and boosts CD4+ T and CD8+ T cell proliferation, leading to direct tumor cell destruction and inhibition of tumor growth. This compound has applications in cancer research and potential in studying immune system disorders.