LGB321 monohydrochloride
Product Specifications
CAS Number
1469925-36-7
Target
MTOR, Pim
Related Pathways
JAK/STAT signaling, Chromatin/Epigenetic, PI3K/Akt/mTOR signaling
Bioactivity
LGB321 monohydrochloride is an effective, selective, and orally active ATP-competitive small molecule inhibitor that targets all three PIM kinases. It inhibits proliferation, the mTOR-C1 signaling pathway, and BAD phosphorylation in various blood cancer-derived cell lines. LGB321 monohydrochloride is suitable for research on hematological malignancies.
Smiles
N(C(=O)C=1N=C(C(F)=CC1)C2=C(F)C=CC=C2F)C=3C(=CC=NC3)N4C[C@H](C)[C@@H](O)[C@H](N)C4.Cl
Molecular Formula
C23H23ClF3N5O2
Molecular Weight
493.91
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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