PARP/EZH2-IN-2
Product Specifications
Target
Histone Methyltransferase, PARP
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair
Bioactivity
PARP/EZH2-IN-2 (compound 12e) functions as a dual inhibitor targeting both PARP1 and EZH2, with IC50 values of 6.89 and 27.34 nM, respectively. This compound exhibits anticancer activity without toxicity to normal cells, achieving synthetic lethality indirectly by increasing PARP1 sensitivity through EZH2 inhibition, and inducing cell death by modulating excessive autophagy.
Molecular Formula
C33H31N7O3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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