CSC-6
Product Specifications
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Bioactivity
CSC-6 is an inhibitor of NLRP3. It significantly reduces the secretion of IL-1? in PMATHP-1 cells, with an IC50 of 2.3 ?M. CSC-6 specifically binds to NLRP3 and prevents its activation by obstructing ASC oligomerization during the NLRP3 assembly process. It effectively alleviates symptoms of sepsis and gout mediated by excessive NLRP3 activation in mouse models.
Molecular Formula
C18H12F3NO2S2
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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