Steffimycin B
Product Specifications
CAS Number
54526-94-2
Target
Antibacterial
Related Pathways
Microbiology/Virology
Bioactivity
Steffimycin B is an anthracycline bacterial metabolite initially isolated from Streptomyces. It binds to DNA, preferentially intercalating at sites containing cytosine and guanine. Steffimycin B exhibits cytotoxicity against MCF-7, KB, NCI-H187, and Vero cells with IC50 values of 3.5, 6.75, 3.28, and 10.5 μM, respectively. It also shows activity against *Mycobacterium tuberculosis* (MIC=5.2 nM), *Bacillus cereus* (MIC=1.56 μg/mL), and *Plasmodium falciparum* (IC50=2.19 μM) .
Smiles
O([C@@H]1C2=C(C=C3C(=C2O)C(=O)C=4C(C3=O)=CC(OC)=CC4O)C(=O)[C@@](C)(O)[C@H]1OC)[C@H]5[C@H](OC)[C@H](O)[C@@H](OC)[C@H](C)O5
Molecular Formula
C29H32O13
Molecular Weight
588.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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