Thalidomide-O-C3-azide
Product Specifications
CAS Number
2758432-00-5
Target
E3 Ligase Ligand-Linker Conjugate
Related Pathways
PROTAC
Bioactivity
Thalidomide-O-C3-azide is a chemically modified version of the cereblon (CRBN) inhibitor Thalidomide through click chemistry. It features an azido group, enabling copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Thalidomide-O-C3-azide serves as a ligand for E3 ubiquitin ligase and a component in E3 Ligase Ligand-Linker Conjugates, facilitating the synthesis of PROTACs.
Smiles
[N-]=[N+]=NCCCOC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3
Molecular Formula
C16H15N5O5
Molecular Weight
357.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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