Thalidomide 4'-ether-PEG2-azide
Product Specifications
CAS Number
2758431-90-0
Target
E3 Ligase Ligand-Linker Conjugate
Related Pathways
PROTAC
Bioactivity
Thalidomide 4'-ether-PEG2-azide is a modified form of the cereblon (CRBN) inhibitor Thalidomide, created through click chemistry. Featuring an azide group, this compound can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. It serves as a ligand for E3 ubiquitin ligase and as a linker conjugate (E3LigaseLigand-Linker Conjugates) for use in PROTACs.
Smiles
[N-]=[N+]=NCCOCCOCCOC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3
Molecular Formula
C19H21N5O7
Molecular Weight
431.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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