LasB-IN-1
Product Specifications
Target
Antibacterial|||NF-?B|||p38 MAPK|||Serine Protease
Related Pathways
MAPK|||Microbiology/Virology|||Proteases/Proteasome|||NF-?B
Bioactivity
LasB-IN-1 (compound 5f) is an efficient and orally active inhibitor of LasB (IC50 = 8.7 ?M) . It effectively inhibits elastase production and biofilm formation in Pseudomonas aeruginosa, while also attenuating inflammatory responses by downregulating MAPK and NF-?B pathways. LasB-IN-1 holds potential as a candidate agent against drug-resistant infections.
Molecular Formula
C20H22F3NO2
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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