Androgen receptor-IN-6

Androgen receptor-IN-6 (compound 16) is an orally active and potent inhibitor of the androgen receptor (IC50=0.12 μMin vitro), targeting its disordered N-terminal domain (NTD) . It demonstrates good permeability in Caco2 cell membranes and exhibits an oral bioavailability (F/%) of 16% in male CD-1 mice.