EGFR/c-Met-IN-1
Product Specifications
CAS Number
3020728-68-8
Target
C-Met/HGFR, EGFR
Related Pathways
Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis
Bioactivity
EGFR/c-Met-IN-1 (compound TS-41) is a dual inhibitor targeting EGFR and c-Met, with IC50 values of 68.1 nM for EGFRL858R and 0.26 nM for c-Met. EGFR/c-Met-IN-1 induces apoptosis and cell cycle arrest in A549-P cells, and reduces phosphorylation of EGFR, c-Met, and downstream AKT. This compound effectively inhibits tumor growth both in vitro and in vivo.
Smiles
O=C(C=C)NC1=CC=2C(=NC=NC2C=C1OC)OC3=CC=C(C=C3F)NC(=O)C=4C(=O)N(C=5C=CC=CC5)N(C4C)C
Molecular Formula
C30H25FN6O5
Molecular Weight
568.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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