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RyR2 stabilizer-1

Product Specifications

CAS Number

3012675-16-7

Target

Calcium Channel

Related Pathways

Membrane transporter/Ion channel, Metabolism

Bioactivity

RyR2 stabilizer-1 (Compound12a) is a potent stabilizer of RyR2 and an activator of SERCA2a, with EC50 values of 2.7 μM for RyR2 and 383 nM for SERCA2. This compound inhibits the leakage of Ca2+ through SR RyR2 while promoting the reuptake of Ca2+ into the SR by SERCA2, suggesting its potential in preventing arrhythmias.

Smiles

OC1(CCCCN(CCCCN2CC3=CC(OC)=CC=C3SCC2)CCCCC4(O)CC4)CC1

Molecular Formula

C28H46N2O3S

Molecular Weight

490.74

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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