β2AR agonist 2

?2AR agonist 2 (compound 8a) is an agonist of the ?2-adrenergic receptor (?2AR) . It is a saturated azacyclic compound featuring a 4- to 7-membered heterocycle. The compound has a chiral structure in the -R form by incorporating a carbon with a requisite hydroxyl group, which significantly stimulates glucose uptake in skeletal muscle cells, thereby enhancing cellular glucose uptake (GU) . ?2AR agonist 2 is applicable in the study of type 2 diabetes (T2D) .