EGFR-IN-91
Product Specifications
CAS Number
3032113-20-2
Target
EGFR
Related Pathways
Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors
Bioactivity
EGFR-IN-91 (compound 9) is an orally active EGFR inhibitor capable of crossing the blood-brain barrier. It effectively inhibits EGFRL858R/C797S and EGFRexon 19del/C797S, leading to tumor regression in patient-derived xenograft (PDX) mouse models. EGFR-IN-91 shows potential for inhibiting locally advanced and metastatic non-small cell lung cancer (NSCLC) driven by EGFR mutations.
Smiles
FC=1C(Cl)=CC=CC1NC=2N=CN=C3C=C(OC)C(OCCON4CCN(C)CC4)=CC32
Molecular Formula
C22H25ClFN5O3
Molecular Weight
461.92
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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