Fluphenazine hydrochloride
Product Specifications
CAS Number
1254-47-3
Target
Sodium Channel, SARS-CoV, Dopamine Receptor
Related Pathways
Microbiology/Virology, GPCR/G Protein, Neuroscience, Membrane transporter/Ion channel
Bioactivity
Fluphenazine hydrochloride is an effective, orally active phenothiazine class dopamine receptor (dopamine receptor) antagonist. It blocks voltage-gated sodium ion channels (sodium channels) in neurons. The compound primarily exerts its effects by antagonizing postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular pathways. It counteracts stereotypy induced by methylphenidate in mice and suppresses climbing behavior. Fluphenazine hydrochloride is used in studying psychoses and diabetic-related painful peripheral neuropathy, with potential to inhibit SARS-CoV-2.
Smiles
Cl.FC(F)(F)C1=CC=C2SC=3C=CC=CC3N(C2=C1)CCCN4CCN(CCO)CC4
Molecular Formula
C22H27ClF3N3OS
Molecular Weight
473.98
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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