PXB17
Product Specifications
Target
C-Fms
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
PXB17 inhibits CSF1R activation (IC50= 1.7 nM) by blocking the PI3K/AKT/mTORC1 signaling pathway. It is effective orally, significantly suppresses the growth of colorectal cancer (CRC), enhances the efficacy of PD-1 monoclonal antibodies (PD-1mAb), and reduces the recurrence of CRC tumors.
Molecular Formula
C29H35N7O4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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