2-PyriMidinaMine, 4-[3-fluoro-5- (4-Morpholinyl) phenyl
Product Specifications
CAS Number
1128096-64-9
Target
JNK|||ROS
Related Pathways
MAPK|||Immunology/Inflammation
Purity
0.9994
Bioactivity
2-Pyridinamine, 4-[3-fluoro-5- (4-morpholinyl) phenyl] (Compound 9l) is an ATP-competitive JNK (c-Jun N-terminal kinase) inhibitor with IC?? values of 0.099 ?M and 0.148 ?M for JNK1 and JNK3 respectively, exhibiting the advantage of blood-brain barrier penetration. 2-Pyridinamine, 4-[3-fluoro-5- (4-morpholinyl) phenyl] inhibits c-Jun phosphorylation and reactive oxygen species (ROS) generation, making it suitable for neurodegenerative disease research.
Smiles
FC1=CC(=CC(=C1)N2CCOCC2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5N=C(N=C5)N6CCOCC6
Molecular Formula
C26H27FN8O2
Molecular Weight
502.54
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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