Z57346765 hydrochloride
Product Specifications
Target
Others
Related Pathways
Others
Bioactivity
Z57346765 hydrochloride is an inhibitor of phosphoglycerate kinase 1 (PGK1) that binds to the ADP binding site, with a K\ (_D\) value of 2.09 x 10?? M, thereby reducing the metabolic enzyme activity of PGK1, glucose consumption, and lactate production. Additionally, it inhibits DNA replication, impairs DNA damage repair, and induces cell cycle arrest in renal clear cell carcinoma (KIRC) cells.
Smiles
OCCNC1=NC(NC2=CC=C(C)C=C2)=NC3=CC=CC=C31.Cl
Molecular Formula
C17H19ClN4O
Molecular Weight
330.81
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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