BBI-355
Product Specifications
CAS Number
2871056-82-3
Target
Chk
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.
Smiles
O(C1=C(C(OC)=CC=C1)C2=CC(NC=3C=NC(C#N)=CN3)=NN2)[C@@H]4C[C@@H](N)C4
Molecular Formula
C19H19N7O2
Molecular Weight
377.4
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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