ATC-324
Product Specifications
CAS Number
2925060-81-5
Target
Androgen Receptor
Related Pathways
Endocrinology/Hormones
Bioactivity
ATC-324 is a potent autophagy-targeting chimera (AUTOTAC) degrader of the androgen receptor (AR) with a DC50 of 2.05 µM. It induces autophagic-lysosomal degradation of AR, decreases nuclear AR and AR-V7 activity, and exhibits cytotoxic effects on AR-positive prostate cancer cells, making it useful for prostate cancer research.
Smiles
S=C1N(C(=O)C(C)(C)N1C2=CC(F)=C(C(NCCOCCOCCOCCOCCNC[C@H](COC3=CC(OCC4=CC=C(F)C=C4)=C(OCC5=CC=C(F)C=C5)C=C3)O)=O)C=C2)C6=CC(C(F)(F)F)=C(C#N)C=C6
Molecular Formula
C53H55F6N5O10S
Molecular Weight
1068.09
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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