TCN 237 hydrochloride
Product Specifications
CAS Number
1784252-90-9
Target
Others|||iGluR
Related Pathways
Others|||Neuroscience|||Membrane transporter/Ion channel
Bioactivity
TCN 237 serves as an antagonist of NR2B subunit-containing NMDA receptors, with a Ki value of 0.85 nM. It specifically blocks glutamate and glycine-induced currents in whole-cell patch-clamp assays when using L-M (TK-) cells expressing NR2B subunit-containing NMDA receptors. This is in contrast to its effect on L-M (TK-) cells with NR2A- or NR2D subunit-containing receptors and HEK293 cells with NR2C subunit-containing receptors. Additionally, TCN 237 at 3 mg/kg dosage mitigates carrageenan-induced mechanical hyperalgesia in rats.
Smiles
FC1=C(CC2CCN(CC2)CC3=NC4=C(N3)C=CC(O)=C4)C=CC=C1.Cl.Cl
Molecular Formula
C20H24Cl2FN3O
Molecular Weight
412.33
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/351432388615602273/T207772
Available Sizes
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