LD2
Product Specifications
CAS Number
1134334-55-6
Target
Others|||Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic|||Others
Bioactivity
LD2 is a protein arginine methyltransferase 9 (PRMT9; IC50 = 0.9 µM) inhibitor. It can reduce the proliferation ability of Rec-1 and Raji lymphoblast cells, UPN1 mantle cell lymphoma, BL-41 Burkitt lymphoma, and OCI-Ly3 diffuse large B-cell lymphoma (DLBCL) cells (IC50s = 2.5-5 µM) . LD2 (2.5 µM) can induce G2/M phase cell cycle arrest in THP-1 acute myeloid leukemia (AML) cells and reduce the phosphorylation levels of checkpoint kinases 1 (Chk1) and Chk2 in their cells.
Smiles
ClC1=NC=NC=2C=3C=C(OC)C=CC3N(C12)C
Molecular Formula
C12H10ClN3O
Molecular Weight
247.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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