ABP/PPAR modulator 1
Product Specifications
Target
FABP, PPAR
Related Pathways
DNA Damage/DNA Repair, Metabolism
Bioactivity
ABP/PPAR modulator 1 is an orally active multi-regulator of FABP and PPAR, exhibiting IC50 values of 0.65 μM for FABP1 and 1.08 μM for FABP4, and EC50 values of 9.19 μM, 2.20 μM, and 1.58 μM for PPARα, PPARγ, and PPARδ, respectively. It demonstrates potent activity against metabolic dysfunction-associated steatohepatitis (MASH) . Additionally, ABP/PPAR modulator 1 dose-dependently improves various pathological features of fatty liver in a WD + Carbon tetrachloride-induced MASH mouse model.
Smiles
COC1=CC=C(/C=C/C2=CC(OC)=CC(OCC3=CC=C(OC(C(N[C@@H](C(O)=O)CC(C)C)=O)(C)C)C=C3)=C2)C=C1
Molecular Formula
C33H39NO7
Molecular Weight
561.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
