TRPV1 antagonist 11
Product Specifications
Target
Opioid Receptor, TRP/TRPV Channel
Related Pathways
Membrane transporter/Ion channel, Neuroscience, Endocrinology/Hormones, GPCR/G Protein
Bioactivity
TRPV1 antagonist 11 (compound 2ac) is a highly potent TRPV1 antagonist with an IC50 of 29.3 nM. It also acts as a μ-opioid receptor (MOR) agonist with a Ki of 60.3 nM. This pyrimidinylpiperazine compound provides analgesic effects by antagonizing TRPV1 and activating MOR. In mouse models of formalin-induced pain, TRPV1 antagonist 11 demonstrates effective dose-dependent antinociceptive properties.
Molecular Formula
C31H37N7O2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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