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PARP14 inhibitor 2

Product Specifications

CAS Number

3064731-00-3

Target

PARP

Related Pathways

Chromatin/Epigenetic, DNA Damage/DNA Repair

Bioactivity

PARP14 inhibitor2 (Compound 3) is an orally active and highly selective PARP14 inhibitor with an IC50 value of less than 30 nM. It effectively inhibits the mono ADP-ribosyltransferase activity of PARP14 and modulates IFN-γ and IL-4 signaling, thereby reversing pro-tumor macrophage polarization and suppressing anti-tumor inflammatory responses. PARP14 inhibitor2 holds potential for research in PARP14-related conditions such as tumors, atopic dermatitis, and autoimmune diseases.

Smiles

O=C1N=C(NC2=CC(OCC34CCC(NC(=O)C)(CC3)CC4)=CC(F)=C12)CSC5CCOCC5

Molecular Formula

C25H32FN3O4S

Molecular Weight

489.6

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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