PARP14 inhibitor 2
Product Specifications
CAS Number
3064731-00-3
Target
PARP
Related Pathways
Chromatin/Epigenetic|||DNA Damage/DNA Repair
Bioactivity
PARP14 inhibitor2 (Compound 3) is an orally active and highly selective PARP14 inhibitor with an IC50 value of less than 30 nM. It effectively inhibits the mono ADP-ribosyltransferase activity of PARP14 and modulates IFN-? and IL-4 signaling, thereby reversing pro-tumor macrophage polarization and suppressing anti-tumor inflammatory responses. PARP14 inhibitor2 holds potential for research in PARP14-related conditions such as tumors, atopic dermatitis, and autoimmune diseases.
Smiles
O=C1N=C(NC2=CC(OCC34CCC(NC(=O)C)(CC3)CC4)=CC(F)=C12)CSC5CCOCC5
Molecular Formula
C25H32FN3O4S
Molecular Weight
489.6
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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