SM875
Product Specifications
CAS Number
919023-94-2
Target
Others
Related Pathways
Others
Bioactivity
SM875 is a degrader specifically targeting the cellular prion protein (PrP) with an IC50 of 7.87 ?M. By binding to the folding intermediates of PrP, SM875 facilitates their degradation via the autophagy-lysosome pathway. It acts exclusively on nascent, immature PrP molecules and does not affect mature PrP synthesized beforehand. SM875 has the potential to inhibit prion replication, making it a promising compound for research in neurodegenerative diseases, particularly prion diseases.
Smiles
O=C1NC2=C(C=NN2C3=CC=C(Br)C=C3)C(C4=CC=C(O)C(OC)=C4)C1
Molecular Formula
C19H16BrN3O3
Molecular Weight
414.25
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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