Carbonic anhydrase inhibitor 32
Product Specifications
Target
Na-K-Cl cotransporter, Carbonic Anhydrase, mTOR
Related Pathways
Metabolism, Membrane transporter/Ion channel, PI3K/Akt/mTOR signaling
Bioactivity
Carbonic anhydrase inhibitor32 (compound 5B) is an orally active, selective inhibitor of hCA (carbonic anhydrase) II/VII, with Ki values of 6.3 nM for hCA II, 10.1 nM for hCA VII, and 681 nM for hCA I. It shows potential for neuroprotection and anticonvulsant effects by reducing mTOR activation and increasing hippocampal KCC2 levels.
Smiles
O=C(C1=C(C)N(C2=CC=C(S(N)(=O)=O)C=C2)N=N1)N/N=C/C3=CC=CC=C3
Molecular Formula
C17H16N6O3S
Molecular Weight
384.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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