T0080
Product Specifications
CAS Number
2785323-68-2
Target
Interleukin, Apoptosis, Reactive Oxygen Species
Related Pathways
Apoptosis, Immunology/Inflammation, NF-κB, Metabolism
Bioactivity
T0080 is an FPR-1 antagonist. It reduces apoptosis (Apoptosis) and inhibits the production of reactive oxygen species (ROS) and pro-inflammatory cytokines (TNF-α and IL-1β) in plaque macrophages within ApoE−/− mouse models, thereby slowing the progression of atherosclerosis.
Smiles
O=C1C2=NNC(C=3C=C(C=CC3O)C)=C2C(C4=CC=C(C=C4)C(F)(F)F)N1C5CCOCC5
Molecular Formula
C24H22F3N3O3
Molecular Weight
457.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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