What is the catalog number for HQY1428?

The catalog number for HQY1428 is T207664.

What sizes are available for HQY1428?

HQY1428 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does HQY1428 come in?

HQY1428 is available in 2 different pack sizes.

HQY1428 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures HQY1428?

HQY1428 is manufactured by Molfinity.

What is the estimated delivery time for HQY1428?

Estimated delivery time for HQY1428 is approximately 10 business day(s), depending on your location.

HQY1428

Product Specifications

Target

DNA/RNA Synthesis, Apoptosis, CDK

Related Pathways

Apoptosis, DNA Damage/DNA Repair, Cell Cycle/Checkpoint

Bioactivity

HQY1428 is an orally active CDK12 inhibitor. It impedes DNA replication, causing cell cycle arrest at the G2/M phase in SKOV3 cells, and induces DNA double-strand breaks as well as apoptosis. In the SKOV3 xenograft mouse model, HQY1428 demonstrates antitumor activity. Additionally, when combined with the HER2 inhibitor Lapatinib in the NCI-N87 xenograft mouse model, HQY1428 produces a synergistic therapeutic effect.