HQY1428
Product Specifications
Target
DNA/RNA Synthesis|||Apoptosis|||CDK
Related Pathways
Apoptosis|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint
Bioactivity
HQY1428 is an orally active CDK12 inhibitor. It impedes DNA replication, causing cell cycle arrest at the G2/M phase in SKOV3 cells, and induces DNA double-strand breaks as well as apoptosis. In the SKOV3 xenograft mouse model, HQY1428 demonstrates antitumor activity. Additionally, when combined with the HER2 inhibitor Lapatinib in the NCI-N87 xenograft mouse model, HQY1428 produces a synergistic therapeutic effect.
Molecular Formula
C25H28ClFN6O3S
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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