CYP2E1-IN-1
Product Specifications
CAS Number
38205-55-9
Target
ROS, Nrf2, Cytochromes P450, Reactive Oxygen Species
Related Pathways
Metabolism, Immunology/Inflammation, NF-κB
Bioactivity
CYP2E1-IN-1 (Compound 10) is an orally active inhibitor of cytochrome P450 2E1 (CYP2E1) with a dissociation constant (Kd) of 7.02 μM, an IC50 of 1.64 μM, and a Ki of 0.897 μM. It alleviates pancreatic damage by activating the Nrf2/HO-1 signaling pathway and inhibiting ROS production. CYP2E1-IN-1 demonstrates significant anti-inflammatory and antioxidant properties, effectively reducing inflammation and oxidative stress in severe acute pancreatitis (SAP) . It is suitable for the study of SAP and other inflammation-related conditions.
Smiles
O=C(C=1SC=NC1C)C
Molecular Formula
C6H7NOS
Molecular Weight
141.19
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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