MS2133
Product Specifications
Target
PROTACs, Histone Methyltransferase
Related Pathways
PROTAC, Chromatin/Epigenetic
Bioactivity
MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.
Molecular Formula
C58H66ClF3N14O11S2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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