PLK1-IN-15
Product Specifications
CAS Number
3068529-37-0
Target
Apoptosis, PLK
Related Pathways
Cell Cycle/Checkpoint, Apoptosis
Bioactivity
PLK1-IN-15 is a PLK1 inhibitor with an IC50 of 38.5 nM. It exhibits antiproliferative effects on HepG2, Huh7, H1299, and A549 cells, with IC50 values of 2.03, 2.08, 4.79, and 17.11 μM, respectively. Additionally, PLK1-IN-15 can induce cell cycle arrest in the G2/M phase and trigger apoptosis (Apoptosis), demonstrating anticancer activity.
Smiles
O=C(OC)C1=C(SC2=C1CCCC2)NC3=NC(=NC=C3N(=O)=O)NC4=CC=C(C=C4)N5CCN(C)CC5
Molecular Formula
C25H29N7O4S
Molecular Weight
523.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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