CDK9 degrader-1
Product Specifications
Target
CDK
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
CDK9degrader-1 is a selective CDK9 degrader (DC50: 0.4073 μM) . It recruits ATG101 to initiate the autophagy-lysosome pathway and forms autophagosomes by recruiting LC3, which then fuse with lysosomes to degrade CDK9 and its partner protein, Cyclin T1 (DC50: 1.215 μM) . CDK9degrader-1 induces caspase 3-mediated apoptosis and exhibits antitumor activity in a mouse HCT116 xenograft model.
Smiles
ClC1=CC=CC(Cl)=C1C(NC2=CNN=C2C(NC3CCN(C(CCC(NC4=C(CCC5)C5=CC6=C4CCC6)=O)=O)CC3)=O)=O
Molecular Formula
C32H34Cl2N6O4
Molecular Weight
637.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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