TrxR-IN-8
Product Specifications
CAS Number
2857180-28-8
Target
Apoptosis|||Reactive Oxygen Species
Related Pathways
Metabolism|||NF-?B|||Apoptosis|||Immunology/Inflammation
Bioactivity
TrxR-IN-8 (Compound 6f) is a selective inhibitor of TrxR with an IC50 of 10.2 ?M. It induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species, reducing intracellular thiols, and lowering the glutathione/glutathione disulfide ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells.
Smiles
[I-].O(C=1C=C(OC)C=2C=3C=CC=CC3C=[N+](C2C1)C)C
Molecular Formula
C16H16INO2
Molecular Weight
381.21
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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