TBK1-IN-2
Product Specifications
CAS Number
3075572-35-6
Target
IκB/IKK
Related Pathways
NF-κB
Bioactivity
TBK1-IN-2 (Compound A1) is a potent inhibitor of TBK1 with an IC50 of 775 pM. It binds to TBK1 through stable hydrogen bonding and π-π stacking interactions, thereby inhibiting the phosphorylation of IRF3. TBK1-IN-2 works in synergy with TNF/IFNγ to enhance immune-mediated tumor cell death and is applicable in cancer immunotherapy research.
Smiles
O=C(OCC=1C=CC=CC1)NC2CCN(C(=O)NC3=CNN=C3C4=NC=5C=C(OC)C(OC)=CC5N4)CC2
Molecular Formula
C26H29N7O5
Molecular Weight
519.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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