EGFR-IN-160
Product Specifications
CAS Number
2172879-84-2
Target
EGFR
Related Pathways
JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
EGFR-IN-160 is an EGFR inhibitor with IC50 values of 1.62, 0.49, and 0.98 μM for EGFRWT, EGFRT790M, and EGFRL858R/T790M/C797S, respectively. It can induce cell cycle arrest at the G2/M and S phases and apoptosis (Apoptosis) in NCI-H522 cells, demonstrating anticancer properties. Additionally, EGFR-IN-160 exhibits antioxidant activity against DPPH (IC50: 12.11 μM) and H2O2 (IC50: 8.89 μM) .
Smiles
O=C1N=C(C=C(N1)C=2C=CC(O)=C(OC)C2)C=3OC=CC3
Molecular Formula
C15H12N2O4
Molecular Weight
284.27
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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