CDK9/EZH2-IN-1
Product Specifications
CAS Number
3081246-18-3
Target
Histone Methyltransferase, CDK
Related Pathways
Chromatin/Epigenetic, Cell Cycle/Checkpoint
Bioactivity
CDK9/EZH2-IN-1 is a dual-target inhibitor of CDK9 and EZH2 with IC50 values of 83.9 nM and 108.6 nM, respectively. It induces apoptosis and causes DNA double-strand breaks (DSB) . Additionally, CDK9/EZH2-IN-1 inhibits the proliferation of MKN45, MDA-MB-453, and SW620 cancer cells, with respective IC50 values of 136.3 nM, 171.3 nM, and 315.7 nM.
Smiles
O=C(NCC=1C(=O)NC(=CC1C)C)C2=CC(=CC3=C2C=NN3C(C)C)C=4C=NC(=CC4)N5CCN(CC5)CCN6CCC(C(=O)NC7=NC=C(S7)SCC8=NC=C(O8)C(C)(C)C)CC6
Molecular Formula
C47H59N11O4S2
Molecular Weight
906.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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