What is the catalog number for GSK-3α/β-IN-1?

The catalog number for GSK-3α/β-IN-1 is T207522.

What sizes are available for GSK-3α/β-IN-1?

GSK-3α/β-IN-1 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does GSK-3α/β-IN-1 come in?

GSK-3α/β-IN-1 is available in 2 different pack sizes.

Is GSK-3α/β-IN-1 in stock?

GSK-3α/β-IN-1 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures GSK-3α/β-IN-1?

GSK-3α/β-IN-1 is manufactured by Molfinity.

What is the estimated delivery time for GSK-3α/β-IN-1?

Estimated delivery time for GSK-3α/β-IN-1 is approximately 10 business day(s), depending on your location.

GSK-3α/β-IN-1

Product Specifications

CAS Number

1574354-24-7

Target

GSK-3, PKA

Related Pathways

PI3K/Akt/mTOR signaling, Stem Cells, Tyrosine Kinase/Adaptors

Bioactivity

GSK-3α/β-IN-1 is a GSK-3α/β inhibitor with IC50 values of 0.265 μM for GSK-3α and 0.255 μM for GSK-3β. It also inhibits PKA with an IC50 of 0.188 μM. GSK-3α/β-IN-1 effectively reduces cell viability in three glioblastoma (GBM) cell lines (IC50: 3-6 μM over 72 hours) without being toxic to human astrocytes, and it exhibits good metabolic stability. Additionally, it shows potential central nervous system activity in a whole human blood-brain barrier (BBB) GBM model.