GSK-3?/?-IN-1
Product Specifications
CAS Number
1574354-24-7
Target
GSK-3|||PKA
Related Pathways
PI3K/Akt/mTOR signaling|||Stem Cells|||Tyrosine Kinase/Adaptors
Bioactivity
GSK-3?/?-IN-1 is a GSK-3?/? inhibitor with IC50 values of 0.265 ?M for GSK-3? and 0.255 ?M for GSK-3?. It also inhibits PKA with an IC50 of 0.188 ?M. GSK-3?/?-IN-1 effectively reduces cell viability in three glioblastoma (GBM) cell lines (IC50: 3-6 ?M over 72 hours) without being toxic to human astrocytes, and it exhibits good metabolic stability. Additionally, it shows potential central nervous system activity in a whole human blood-brain barrier (BBB) GBM model.
Smiles
OC=1C=CC2=C(OC3=C2NC4=NN=CC4=C3C=5C=CC(=CC5)C(C)C)C1
Molecular Formula
C21H17N3O2
Molecular Weight
343.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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