GSK-3?/?-IN-1

Product Specifications

CAS Number

1574354-24-7

Target

GSK-3|||PKA

Related Pathways

PI3K/Akt/mTOR signaling|||Stem Cells|||Tyrosine Kinase/Adaptors

Bioactivity

GSK-3?/?-IN-1 is a GSK-3?/? inhibitor with IC50 values of 0.265 ?M for GSK-3? and 0.255 ?M for GSK-3?. It also inhibits PKA with an IC50 of 0.188 ?M. GSK-3?/?-IN-1 effectively reduces cell viability in three glioblastoma (GBM) cell lines (IC50: 3-6 ?M over 72 hours) without being toxic to human astrocytes, and it exhibits good metabolic stability. Additionally, it shows potential central nervous system activity in a whole human blood-brain barrier (BBB) GBM model.