CS-VIP 8
Product Specifications
Target
Histone Methyltransferase|||JAK
Related Pathways
Stem Cells|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic|||JAK/STAT signaling|||Angiogenesis
Bioactivity
CS-VIP 8 is a selective allosteric inhibitor of the WDR5 protein (Ki= 0.008 ?M) . It induces conformational changes in the MLL1 complex, causing the dissociation of MLL1 from the complex and inhibiting MLL1 histone methyltransferase activity, thereby regulating HOX gene expression. CS-VIP 8 shows potential for research in hematological diseases such as leukemia.
Molecular Formula
C43H52F4N12O7
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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