FAK-IN-26
Product Specifications
CAS Number
2801785-12-4
Target
FAK
Related Pathways
Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis
Bioactivity
FAK-IN-26 is a blood-brain barrier-penetrating inhibitor of Focal Adhesion Kinase (FAK) with an IC50 of 0.87 nM. It significantly reduces tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 exhibits potent anticancer activity, achieving tumor inhibition rates of 59.15% and 57.9% in A549 and SKOV-3 tumor mouse models, respectively.
Smiles
O=C(NC)C=1C=CC=CC1NC2=NC(=NC=C2Br)NC3=CC=C(OCCF)C=C3
Molecular Formula
C20H19BrFN5O2
Molecular Weight
460.3
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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