What is the catalog number for CDK12-IN-8?

The catalog number for CDK12-IN-8 is T207456.

What sizes are available for CDK12-IN-8?

CDK12-IN-8 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does CDK12-IN-8 come in?

CDK12-IN-8 is available in 2 different pack sizes.

Is CDK12-IN-8 in stock?

CDK12-IN-8 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CDK12-IN-8?

CDK12-IN-8 is manufactured by Molfinity.

What is the estimated delivery time for CDK12-IN-8?

Estimated delivery time for CDK12-IN-8 is approximately 10 business day(s), depending on your location.

CDK12-IN-8

Product Specifications

CAS Number

2928619-86-5

Target

CDK

Related Pathways

Cell Cycle/Checkpoint

Bioactivity

CDK12-IN-8 (Compound Cpd143) is an orally active, highly selective inhibitor of cyclin-dependent kinase 12 (CDK12) . It blocks the phosphorylation of serine 2 in the C-terminal domain (CTD) of RNA polymerase II, thereby interfering with gene transcription elongation and DNA damage repair pathways. CDK12-IN-8 holds potential for research in cancers with high CDK12 expression, such as small cell lung cancer and triple-negative breast cancer.