(2S,3S,11bR) -Dihydrotetrabenazine
Product Specifications
CAS Number
862377-27-3
Target
Monoamine Transporter
Related Pathways
Membrane transporter/Ion channel
Bioactivity
(2S,3S,11bR) -Dihydrotetrabenazine ((2S,3S,11bR) -DHTBZ) is a highly selective inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki value of 593 nM. It suppresses the vesicular transport of monoamine neurotransmitters, such as dopamine and serotonin, leading to reduced release into the synaptic cleft. This compound holds potential for research in Huntington's disease and other hyperkinetic movement disorders.
Smiles
O(C)C=1C=C2[C@@]3(N(C[C@H](CC(C)C)[C@@H](O)C3)CCC2=CC1OC)[H]
Molecular Formula
C19H29NO3
Molecular Weight
319.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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