CDK9/HDAC1/HDAC3-IN-1
Product Specifications
CAS Number
2197029-81-3
Target
Apoptosis|||CDK|||HDAC
Related Pathways
Chromatin/Epigenetic|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Apoptosis
Bioactivity
CDK9/HDAC1/HDAC3-IN-1 is a dual inhibitor targeting CDK9 and HDAC enzymes. It potently suppresses the activity of CDK9, HDAC1, and HDAC3, with IC50 values of 0.17 ?M, 1.73 ?M, and 1.11 ?M, respectively. The compound inhibits cancer cell growth by inducing apoptosis and causing cell cycle arrest at the G2/M phase. In a mouse model using TNBC MDA-MB-231 xenografts, it effectively hinders tumor progression. This compound exhibits broad-spectrum anticancer effects, notably against breast cancer, cervical cancer, and liver cancer.
Smiles
O=C(NC=1C=CC=CC1N)C2=CC=3C=C(C=CC3N2)NC=4N=CC=C(N4)C=5SC(=NC5C)NC
Molecular Formula
C24H22N8OS
Molecular Weight
470.55
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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