PROTAC GPX4 degrader-4
Product Specifications
CAS Number
3071165-43-7
Target
Glutathione Peroxidase, ROS Kinase, Ferroptosis
Related Pathways
Tyrosine Kinase/Adaptors, Metabolism, Apoptosis
Bioactivity
PROTACGPX4 degrader-4 is a GPX4 PROTAC degrader with a DC50 of 5.32 nM. It inhibits the activity of cancer cell lines RT4, T24, and J82 with IC50 values of 0.09, 2.97, and 7.58 μM, respectively. This compound elevates lipid ROS levels and induces ferroptosis in T24 and RT4 cells. In T24 tumor-bearing BALB/c nude mouse models, PROTACGPX4 degrader-4 demonstrates antitumor activity. It is applicable to bladder cancer research.
Smiles
C[C@@H]1[C@]2([C@]34[C@](O[C@H]1OC(CCC(OCCCCCCCCCCCOC5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5)=O)=O)(O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])[H])[H]
Molecular Formula
C43H58N2O13
Molecular Weight
810.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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