MS105
Product Specifications
CAS Number
2408339-39-7
Target
Tyrosinase, PROTACs, Apoptosis
Related Pathways
Apoptosis, Proteases/Proteasome, PROTAC
Bioactivity
MS105 is an orally active, selective protein tyrosine kinase 6 (PTK6) PROTAC degrader. It recruits the VHL E3 ligase through a VHL ligand fragment, facilitating ubiquitination and proteasomal degradation of PTK6, thereby inhibiting the proliferation and migration of breast cancer cells and inducing apoptosis (apoptosis) . MS105 is a promising compound for breast cancer research.
Smiles
N(C=1C=2N(C(=CN2)C=3C=NNC3)C=C(N1)C4CC4)C5=C(F)C=C(C(=O)N6CCN(CC(NCCCCCCCCC(N[C@H](C(=O)N7[C@H](C(NCC8=CC=C(C=C8)C=9SC=NC9C)=O)C[C@@H](O)C7)[C@](C)(C)C)=O)=O)CC6)C=C5
Molecular Formula
C56H70FN13O6S
Molecular Weight
1072.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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