SRI-31255
Product Specifications
CAS Number
905580-86-1
Target
LRRK2
Related Pathways
Autophagy
Bioactivity
SRI-31255 is an orally active LRRK2 inhibitor, with IC50 values of 520 nM for human wild-type (WT) and 427 nM for the G2019S mutant. It inhibits kinase activity by binding to the ATP-binding pocket of LRRK2, providing neuroprotective effects. SRI-31255 serves as a lead compound for developing LRRK2-targeted therapies for Parkinson’s disease research.
Smiles
N([C@@H]1C=2C(CC1)=CC=CC2)C3=C4C(NC=C4)=NC=N3
Molecular Formula
C15H14N4
Molecular Weight
250.3
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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